Manuel Pellegrini knows Real Betis need to inflict a hiding akin to Manchester United's humiliation at Liverpool as Erik ten Hag's side play on the road for the first time since their Anfield annihilation.
Los Verdiblancos are looking to become the second team in Europa League history to overcome a three-goal first-leg deficit to progress.
United ran out 4-1 victors in last Thursday's last-16 tie at Old Trafford - an impressive display of quality and character four days on from their humiliating 7-0 defeat at bitter rivals Liverpool.
That loss equalled the club's heaviest ever defeat and former Manchester City boss Pellegrini knows a similarly incredible collapse is needed if the LaLiga side are to progress on Thursday night.