Victory will see City retain the title regardless of second-placed Liverpool's result against Wolves.
And Guardiola insists his side are focused on the task in hand.
He added: 'We know what we have to do. Be ourselves, give everything we have to win the game.'
Winning the title would be Guardiola's fourth in the last five seasons at City but it would be the first he has actually secured at the Etihad Stadium.