Influential Real Madrid pair Thibaut Courtois and Marcelo have both suffered muscular injuries and will miss the crunch ties with Eibar and Manchester City.
The news will come as a blow to Zinedine Zidane, whose side are still reeling from the defeat by Real Betis which has put them behind Barcelona in the LaLiga table.
Courtois and Marcelo both started the match in Seville, but have suffered injuries to their left thigh and hamstring respectively.
Courtois managed to play the full 90 minutes, while Marcelo was replaced by Ferland Mendy with half an hour to play.