The hosts will be desperate for a win to take them out of the relegation zone. But they have not won since mid-January — although they are undefeated in their last three matches.
Pep Guardiola's City side would create a 16-point gap at the top of the Premier League table with a win and edge closer to capturing the first title of his reign. They will be without Sergio Aguero.
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And it's an interesting one.