Manchester City's Premier League title defence will begin in north London with Pep Guardiola's side taking on Tottenham.
City will be looking to get off to good start but face a tricky set of early fixtures with away trips to Leicester, Chelsea and Liverpool all to come before October 2.
They will play rivals Manchester United at Old Trafford on November 6 with the return fixture at the Etihad coming on March 5.
Read the full list below:
14/08/2021 15:00 Tottenham Hotspur v Manchester City
21/08/2021 15:00 Manchester City v Norwich City
28/08/2021 15:00 Manchester City v Arsenal
11/09/2021 15:00 Leicester City v Manchester City
18/09/2021 15:00 Manchester City v Southampton
25/09/2021 15:00 Chelsea v Manchester City
02/10/2021 15:00 Liverpool v Manchester City
16/10/2021 15:00 Manchester City v Burnley
23/10/2021 15:00 Brighton v Manchester City
30/10/2021 15:00 Manchester City v Crystal Palace
06/11/2021 15:00 Manchester United v Manchester City
20/11/2021 15:00 Manchester City v Everton
27/11/2021 15:00 Manchester City v West Ham United
30/11/2021 19:45 Aston Villa v Manchester City
04/12/2021 15:00 Watford v Manchester City
11/12/2021 15:00 Manchester City v Wolverhampton
15/12/2021 20:00 Manchester City v Leeds United
18/12/2021 15:00 Newcastle United v Manchester City
26/12/2021 15:00 Manchester City v Leicester City
28/12/2021 15:00 Brentford v Manchester City
01/01/2022 15:00 Arsenal v Manchester City
15/01/2022 15:00 Manchester City v Chelsea
22/01/2022 15:00 Southampton v Manchester City
09/02/2022 20:00 Manchester City v Brentford
12/02/2022 15:00 Norwich City v Manchester City
19/02/2022 15:00 Manchester City v Tottenham Hotspur
26/02/2022 15:00 Everton v Manchester City
05/03/2022 15:00 Manchester City v Manchester United
12/03/2022 15:00 Crystal Palace v Manchester City
19/03/2022 15:00 Manchester City v Brighton
02/04/2022 15:00 Burnley v Manchester City
09/04/2022 15:00 Manchester City v Liverpool
16/04/2022 15:00 Wolverhampton v Manchester City
23/04/2022 15:00 Manchester City v Watford
30/04/2022 15:00 Leeds United v Manchester City
07/05/2022 15:00 Manchester City v Newcastle United
15/05/2022 15:00 West Ham United v Manchester City
22/05/2022 16:00 Manchester City v Aston Villa
All fixtures are subject to change once live TV schedule has been finalised.