Chile goalkeeper Claudio Bravo and midfielder Arturo Vidal left Thursday's World Cup qualifier game with apparent injuries in a goalless draw at Colombia.
The Manchester City keeper was forced to depart in the 64th minute and was replaced by Johnny Herrera.
He took an early knock after contact with Colombia's Miguel Borja, then collided with Santiago Arias in the second half and could not continue.
Charles Aranguiz also had to leave the game 10 minutes later for La Roja, who were already without Arsenal forward Alexis Sanchez, and Bayern Munich star Vidal was stretchered off the pitch in the 89th minute.