LSU vs No. 8 Oklahoma: Final odds and score prediction

Western Kentucky v LSU | Sean Gardner/GettyImagesThe LSU Tigers head to Norman to face the Oklahoma Sooners in the final regular season game of the 2025 season. The Tigers entered the season with hopes of competing for a National Championship, but now are just looking to salvage and eight-win season.

Interim head coach Frank Wilson is 2-1 at the helm of the LSU program, and looking to lead the Tigers to a three-game winning streak to close the season. It's a tough task, as the Sooners are ranked as the No. 8 team in the country and own one of the best defenses in college football. As kick-off draws nearer, here is a look at the updated LSU vs Oklahoma betting odds as well as a score…