The LSU vs Clemson meeting on Saturday has the potential to deliver an instant classic. Both teams are ranked in the top-ten of the preseason AP Top 25 Poll, and both are led by veteran quarterbacks in Garrett Nussmeier and Cade Klubnik. Both gunslingers could be top-ten picks in the 2026 NFL Draft.
Both Tiger programs have national title hopes this season, which means a lot is on the line in this highly-anticipated matchup. Here is a look at the current LSU vs Clemson odds, as well as a prediction.
Current LSU vs Clemson odds
The spread for this matchup has hovered back-and-forth between 3.