The 2025 college football season kicks off with one of the biggest nonconference matchups of the year as LSU travels to Death Valley to face Clemson.
With potential early College Football Playoff implications and Heisman considerations, Clemson opens as a 4.5-point favorite at home, leaning on continuity and experience, while LSU brings elite talent and one of the most dynamic quarterbacks in the country.
With both offenses built to move the ball and plenty of unknowns on defense, this matchup sets up to be one of the most compelling Week 1 showdowns.
