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Wednesday afternoon Cardinal news and notes

—Spread check: Notre Dame by 5.5.

—Natalie Pierre is the only member of the Courier Journal sports staff picking Louisville to upset Notre Dame.

—The U of L offense is expecting a “great challenge” from the Fighting Irish defense.

—Notre Dame has been absolutely dominant against the ACC in 2017.

In the last seven Notre Dame vs. ACC games leading up to last weekend, the Irish won them all by at least 13 points. Five were by 21 or more.

A lot of teams lose to Notre Dame in the regular season.