As I've written in this space multiple times before, Louisville struggles to handle weakside/backside linebackers. This observation started three years ago when Ben Boulware stepped in for an injured starter and had the first big game of his career. Last year Arrius Moore had a career day for NC State at his weakside spot, also. Anyone remember Steven Daniels last year for BC? That backside linebacker spot has caused many issues for Louisville and I'm not sure they've figured out how to stop it.
Houston runs a 3-4 that is similar to Louisville's base defense under Todd Grantham.