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The biggest problem Louisville will face vs. Clemson in Week 12

As Louisville looks to take down Clemson for the second-straight season, limiting TJ Parker's game-wrecking ability has to be priority No. 1.

Clemson Tigers defensive end T.J. Parker (3) | Bob Donnan-Imagn Images

Even in a down year, Clemson found its way to the top of the ACC and into the 12-team College Football Playoff last season. However, Louisville was one of the teams that took advantage of the dip, knocking off the Tigers 33-21 in Death Valley behind a breakout performance from freshman running back Isaac Brown with 20 carries for 151 yards and a touchdown on the massive stage.