Louisville football will travel to Pittsburgh this weekend for the Cardinals' first ACC game of the 2025 season. While last year's game was an absolute blowout, with the Cards winning 37-9, the feeling for this game is much different.
The Cardinals are now favored by 4.5 points on the road at Acrisure Stadium, and a big reason is the uncertainty of Pitt's star running back Desmond Reid. ESPN's Football Power Index gives the Cardinals the better chance of winning as they give Louisville a 57 percent chance of winning Saturday, while Pitt just has a 43 percent chance.