Louisville football will look to earn their first Power 4 win of the 2025 season this weekend when the Cardinals take on the Pittsburgh Panthers. Louisville has dominated its three opponents so far, but with its ACC schedule now here, it is clear that Louisville fans will honestly know just how good this team is.
The Cardinals beat Pitt last year 37-9 and dominated just every phase of the ball. Now, they must do the same thing in 2025 with a new quarterback in Miller Moss and potentially a thin running back room, depending on whether Isaac Brown and Duke Watson are ready to go.