Louisville football's 2025 season just took a massive hit from their gut-wrenching overtime loss, as the Cardinals now will have a huge uphill battle the rest of the season. Entering the showdown with the Virginia Cavaliers, the Cardinals were 6.5-point favorites, but Louisville's costly turnovers cost them the game, and in some eyes, their season.
The Cardinals had the third-best odds to win the ACC entering Saturday, with +950 odds, but after Louisville's loss, the Cardinals' fans saw their chances plummet. FanDuel updated its odds after Saturday's showdowns, and Miami and Virginia saw their odds skyrocket, but Louisville, unfortunately, is being given a harsh reality check.