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Louisville vs Pitt spread is changing fast after crucial injury updates

The Louisville football team is traveling to the Pitt Panthers this Saturday for a crucial Week 5 matchup. The Cardinals sit at 3-0, while the Panthers sit at 2-1, making this matchup crucial for both ACC Title chances.

The Cardinals entered the season with the third-best odds to win the ACC Championship, but with Clemson's decline and Florida State's and Georgia Tech's rise, the Cards now sit with the fourth-best odds. Louisville has never won the ACC Championship game, and if they want to make it to Charlotte, this showdown with Pitt is massive.

Louisville understands their schedule gets tougher down the stretch, and with this matchup on the road, the Cardinals fans are biting their nails just hoping they can leave with a win.