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Louisville vs James Madison: How to watch, odds, injuries, weather, announcers, and series history

Louisville football got off to a dominant start for the 2025 season as the Cardinals thumped Eastern Kentucky 51-17 last Saturday. Jeff Brohm and his Cardinals will now shift their focus to Friday night, where Louisville has a sneaky, challenging opponent in James Madison.

The Dukes are also coming off a solid Week 1 performance as they defeated Weber State 45-10. James Madison is expected to be a great test for Louisville in Week 2 and to get them ready for their ACC play in Week 5 against Pitt. The Cardinals fans cannot wait to watch Louisville play under the lights on a Friday night and pack out L&N Stadium.