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Louisville vs Eastern Kentucky: How to watch, odds, injuries, weather, announcers, and series history

Jeff Brohm will look to secure Louisville football's third straight nine-win season and second 10-win season in three years. Brohm has emerged as one of the best coaches in college football since his arrival at his alma mater, and he will now look to take the Cardinals back to the ACC Championship game, but this time get over the hump and make history by winning the program's first-ever ACC Title.

Eastern Kentucky will travel to Louisville this Saturday to take on the Cardinals for an in-state battle in Week 1. Brohm and the Cardinals have high expectations entering the 2025 season, and it all starts this Saturday against the Cololnels from L&N Stadium.