Back to the Louisville Cardinals Newsfeed

Louisville vs Eastern Kentucky final odds and predictions

The wait is over. Louisville football is officially back as the Cardinals and the Eastern Kentucky Colonels are set to kick off at 3 p.m. local time from L&N Stadium. The Cardinals enter the third season under head coach Jeff Brohm and will look to carry the momentum from last season, as they won their final three games, including a tight Sun Bowl victory over Washington.

Louisville has emerged as a legitimate College Football Playoff contender in 2025 with their highly explosive offense, as the Cardinals' offense will be led by preseason All-American Isaac Brown and USC transfer quarterback Miller Moss.