Louisville football has their biggest game of the 2025 season in four days, and the Cards fans understand this is going to make or break their ACC Title dreams. Louisville had a devastating loss at home two weekends ago when the Cardinals fell short to Virginia in an Overtime loss.
Now, with that massive setback, Louisville faces the challenge of traveling to Miami and facing the No. 2 team in the nation. The Cardinals' loss to Virginia was one the team had to win to stay on track to make the ACC Championship game, but now, after they lost to the Cavaliers, it is clear to the fans that this Friday night against Miami, Louisville must win to keep their ACC Title odds in a reachable range.