Louisville is 5-1 straight up in its last six meetings with Syracuse—4-2 against the spread—stretching back to their days as Big East rivals. Coming off a huge offensive performance, the Cardinals will be big favorites for Friday night's meeting with the Orange at the Carrier Dome.
Point spread: Cardinals opened as 13-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 33.8-8.4 Cardinals (College football picks on every game)
Why the Louisville Cardinals can cover the spread
Louisville opened this season with a 70-14 romp over Charlotte last Thursday, covering as a 38-point favorite.