Louisville football is coming off a wild comeback win over Pitt and is now 4-0 going into their biggest game of the 2025 season. The Virginia Cavaliers are ranked No. 24 in the nation after their win over Florida State and are 4-1 on the season, with their only loss coming to North Carolina State.
Louisville ACC Title odds have been going up and down all season long, but thanks to the Cavaliers, they jumped Florida State, and now sit with the third-best odds to win the ACC, and they have a clear path to make history.