The top-ranked Cardinals defeated the No. 18 Ole Miss Rebels 7-2 Fri. Feb. 14 at Swayze Field.
Louisville (1-0, 0-0), had their deepest run in postseason in program history last season and brought six players back who started at least 30 games.
The game started out slow, without a single run for either team until the fifth inning. Junior Reid Detmers (1-0) allowed just one run and struck out nine in his first five innings this season. Senior Adam Elliott helped hold off the Rebels for two innings then junior Michael Kirian closed the door on Ole Miss (0-1, 0-0) to secure the save.