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3 must-win games that will make or break Louisville’s 2025 season

Related Topics: Louisville, Jeff Brohm

Louisville football enters the 2025 season with the third-best odds to win the ACC Championship at +850, trailing only Clemson (+115) and Miami (+440). Coming off a year where they lost just three conference games — all by a touchdown or less — the Cardinals appear poised for another run at the ACC title under head coach Jeff Brohm.

While marquee matchups against Clemson (at home) and Miami (on the road) stand out, the season’s true tipping points may come elsewhere on the schedule.

Last season, despite beating Clemson, Louisville fell two games short of the ACC Championship due to a November collapse at Stanford and a high-scoring home loss to Miami.