Louisville football opened the 2025 season with a 51–17 rout of Eastern Kentucky. On paper, it was a commanding win, but from a betting perspective, it left something to be desired. The Cardinals were 37.5-point favorites and failed to cover, largely because they didn’t force a single turnover and let the Colonels sneak in late points once the starters sat. For gamblers, winning without covering often feels like a letdown.
Now the competition stiffens. In Week 2, Jeff Brohm’s team faces James Madison, one of the most consistent Group of Five programs of the past decade.