Louisville football has its first game of the 2025 regular season this Saturday against the Eastern Kentucky Colonels. While Louisville is a 38.5-point favorite, the Cardinals will face some solid opponents and encounter a few challenges.
Walt Wells has a 30-26 record with Eastern Kentucky and has earned the respect of Jeff Brohm over the years. Many new faces will highlight the Colonels' team, but some stars are expected to emerge in 2025. So, while the Cardinals should dominate from start and finish, here are three Eastern Kentucky players who could give Louisville football trouble on Saturday.