Darrell Henderson Jr, running back for the Los Angeles Rams was the first to be tasked with stepping up when projected 2021 starter Cam Akers went down in the preseason. Henderson, in his third season after being drafted by the Rams in the third round of the 2019 draft, had a career high 688 yards rushing on 149 carries and five touchdowns while starting in 10 games. He posted a 4.6 yard per carry average after a 4.5 yard per carry average the previous season.
Against the Houston Texans Hendo posted 90 yards rushing and went over 80 yards in three games.