Indianapolis Colts running back Jonathan Taylor will miss Thursday night's game at Denver with an ankle injury.
The Colts (1-2-1) also ruled out linebacker Shaquille Leonard, safety Julian Blackmon and defensive end Tyquan Lewis for the Week 5 game against the Broncos (2-2).
On Tuesday, Colts head coach Frank Reich and Taylor both said they were hopeful that the injury wasn't severe enough to keep him out. "But if you can't go, you can't go," Taylor said.
Taylor, the 2021 NFL rushing champion, sustained the injury in the fourth quarter of Sunday's 24-17 loss against the Tennessee Titans.