The team confirmed that the accident occurred after Garrett, 26, left the practice facility in Berea, Ohio.
Multiple reports said Garrett's 2021 Porsche went off the road and flipped multiple times before coming to a rest.
Details of the crash that happened at about 3 p.m. local team near Wadsworth in Ohio's Medina County were still being gathered. The Ohio State Highway Patrol confirmed there was a female passenger in the vehicle and that both occupants were wearing seatbelts.
Garrett was the No. 1 overall pick in the 2017 NFL Draft and is in his sixth season with the Browns.