Bolles fractured his lower right leg late in the fourth quarter after Colts defensive tackle DeForest Buckner rolled up on him while tackling Broncos running back Mike Boone. Bolles was in tears while being carted off the field.
Per Denver coach Nathaniel Hackett, inside linebacker Josey Jewell is week-to-week with a knee sprain and outside linebacker Baron Browning is day-to-day with a wrist sprain.
"Injuries are a thing that, as a coach, I can't control. I mean, especially the ones that we're having," Hackett said Friday. "It's not things that guys are going to be able to come back from.