and the Arizona Cardinals (+10) on Monday Night Football on ESPN. The Cardinals have been a better team on the road, but I honestly can’t say how that may play into this game; they are considered the home team, though the game will take place at Estadio Azteca in Mexico City.
DraftKings Sportsbook has the 49ers as 8-point favorites. The margin has increased throughout the week due to the uncertainty surrounding some key players for the Cardinals.
Arizona may be without Kyler Murray for the second straight week, but at the time of writing this article, he has yet to be officially ruled out.