Kyle Kuzma added 15 points for the Lakers (17-29), who continued their midseason surge of solid play. Rookie point guard Alex Caruso set career highs with nine points and eight assists, making the most of extensive playing time in the absence of injured Lonzo Ball.
Michael Beasley scored 17 points apiece for the Knicks, who have lost 12 of 16. New York slipped to 2-2 on its seven-game trip.
Ball missed his fourth consecutive game with a sore left knee, and Lakers coach Luke Walton said the rookie point guard might miss several more games.
But Clarkson followed up his 33-point performance Friday against Indiana with another high-energy effort.