The Angels struck for two runs in the ninth to tie it. Jefry Marte's RBI single cut the deficit to 8-7 before he scored the tying run on Craig Gentry's two-out single.
The Cubs, seven days removed from opening their season at Angel Stadium, plated five runs in a third inning that was highlighted by a three-run homer from Heyward and a solo shot by Anthony Rizzo.