The Reds have surged into an eight-point lead after winning each of their opening eight games before the October international break.
They return to domestic action with one of the highlights of the fixture calendar: a trip to Old Trafford to face fierce rivals Manchester United.
And ahead of the clash, Van Dijk outlined his approach to the long race to top the table and how that has been influenced by last season’s second-placed finish.
“I don’t think we have anything to lose,” the Netherlands captain told Sky Sports.
“Man City are the champions, they’re defending their title and we want to get it.