It took extra-time and penalties to decide the European final against Chelsea in Istanbul on Wednesday, so it will be a quick turnaround between matches for Jürgen Klopp's Reds.
Meanwhile, Ralph Hasenhuttl's Saints head into the match on the back of a 3-0 defeat in their season-opening fixture at Burnley and will be eager to rectify that in front of their own fans.
So, what can we expect from the hosts on Saturday? We caught up with chief sports writer at the Southern Daily Echo and Total Saints Podcast co-founder Adam Leitch (@adamleitchsport) to find out.