Naby Keita and Roberto Firmino got the goals at Anfield last week as the Reds extended their unbeaten run against Os Dragoes to seven games.
Liverpool have never lost home or away against the Portuguese outfit and won 5-0 when they met in Porto in the Champions League Round of 16 last season.
So, what can we expect from Sergio Conceicao's side this time around?
We caught up with PortuGOAL editor and World Soccer correspondent Tom Kundert (@PortuGoal1) to find out...
What was the reaction in Portugal to the first leg result?