Trent Alexander-Arnold and Ibrahima Konate come back into defence at Estadio de la Ceramica, while Thiago Alcantara and Fabinho are restored in midfield.
Meanwhile, Mohamed Salah returns in attack for the Reds, with Joe Gomez, Joel Matip, James Milner, Jordan Henderson and Luis Diaz the players to make way.
Liverpool: Alisson, Alexander-Arnold, Konate, Van Dijk, Robertson, Fabinho, Keita, Thiago, Jota, Salah, Mane.
Subs: Kelleher, Milner, Gomez, Henderson, Oxlade-Chamberlain, Jones, Minamino, Tsimikas, Diaz, Origi, Matip, Elliott.