The 19-year-old Academy graduate lines up alongside Virgil van Dijk at the heart of the Reds’ defence at the LNER Stadium.
Elsewhere, Kostas Tsimikas makes his first competitive appearance for the club, while Diogo Jota is on the bench.
Liverpool: Adrian, N. Williams, R. Williams, Van Dijk, Tsimikas, Grujic, Jones, Elliott, Shaqiri, Minamino, Origi.
Subs: Kelleher, Fabinho, Keita, Jota, Wilson, Alexander-Arnold, Van den Berg.