Nathaniel Clyne makes his first appearance of 2017-18 as he begins at right-back, while Ragnar Klavan lines up on the left-hand side of defence.
Georginio Wijnaldum returns in midfield, while Danny Ings and Dominic Solanke are drafted into attack to join Sadio Mane.
Mohamed Salah is left out of the matchday squad after picking up a knock in midweek (groin), but there are places on the bench for Academy youngsters Curtis Jones and Conor Masterson. Roberto Firmino is also among the substitutes. Andy Robertson misses out with a calf problem.
Liverpool: Karius, Clyne, Lovren, Van Dijk, Klavan, Milner, Henderson, Wijnaldum, Mane, Ings, Solanke.