The Jupiler Pro League champions are set to be the club's 130th different European opponent and the 77th in this competition.
The Reds have earned 10 wins, two draws and suffered a single defeat in previous contests with teams from Belgium, having faced Anderlecht, Club Brugge and Standard Liege.
The only reverse came at the hands of Anderlecht in the first leg of the 1978 European Super Cup as Bob Paisley's side lost 3-1.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool last scored four or more goals in successive European games in the 2017-18 Champions League campaign, netting seven at home to Spartak Moscow in the group phase and then five at FC Porto in the knockout stages.