A goal on his 63rd league appearance for the Reds would break Alan Shearer's record of reaching 50 goals in 66 appearances for Blackburn Rovers in 1994.
Liverpool's club record is currently held by Fernando Torres, who notched his half-century over 72 games.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Jürgen Klopp's Liverpool have lost only once in the last seven meetings with Manchester United in all competitions.
The Reds have scored in all but one of the last 10 league visits to Old Trafford.