In a summer of many changes for the club, boss Neil Redfearn had seven players making their league debut during the encounter at Meadow Park, Boreham Wood FC.
The Gunners netted four of their goals in the opening half as their quality and speed in attack caused so many problems for the Reds defence.
The home side made a strong start and took the lead after just five minutes. A cross from the left flank saw the Reds defence caught out and Dutch international Vivianne Miedema pounced to score from close range.
It was 2-0 on 14 minutes with Miedema turning provider for Lisa Evans, who despite losing her balance still managed to find the net.