Today's release of the 2018-19 Premier League fixture list saw the Reds handed an away trip to face Mauricio Pochettino's men on September 15.
Spurs will contest a home game against Fulham before that date but, with test events scheduled at their new stadium across August and September, they are set for a brief return to Wembley.
As such, Jürgen Klopp's men will become the first team to run out as opposition at Spurs' new home.