Mikel Arteta is forced into making one change to the Arsenal team that beat Tottenham 3-1 in last Saturday's north London derby.
Oleksandr Zinchenko has dropped out of the matchday 18 entirely, with Japan's Takehiro Tomiyasu coming in at left-back.
Arsenal: Ramsdale, White, Saliba, Gabriel, Tomiyasu, Partey, Saka, Odegaard, Xhaka, Martinelli, Jesus.
Subs: Turner, Tierney, Nketiah, Holding, Soares, Vieira, Sambi Lokonga, Nelson, Marquinhos.
Liverpool make three changes from their 3-3 draw at home to Brighton last Saturday.
Luis Diaz, Diogo Jota and Darwin Nunez all come into the side, with Fabinho, Roberto Firmino and Fabio Carvalho dropping out.