Plymouth striker David Goodwillie will not feature for the club after being involved in a civil case in Scotland.
The Pilgrims are also without Connor Smith after he was injured in Saturday's 4-2 win against Stevenage.
Liverpool keeper Loris Karius is set to start, but the third-round replay is likely to come too soon for injured pair Nathaniel Clyne and Lucas Leiva.
Right-back Clyne (rib) and midfielder Lucas (knee) both missed Sunday's 1-1 draw at Manchester United.
Liverpool are still unsure about centre-back Joel Matip's availability after being forced to pull him out of the match at Old Trafford amid a dispute with Cameroon's football association.