The Reds will take on London City Lionesses at Prenton Park next Sunday – August 29 – with kick-off at 2pm.
It will mark the end of a busy summer period for the club, with the return of title-winning manager Matt Beard and the arrival of eight new players into the squad.
The COVID-19 pandemic prevented fans from attending all but one game last year and it is hoped a good home crowd can help inspire LFC Women as they begin their campaign against another side who have recruited heavily ahead of 2021-22.
“The team are really looking forward to playing in front of our supporters again,” said Beard.