Both reported to Melwood for day one of pre-season training on Monday, but Jürgen Klopp does not expect to have either available for Saturday’s match at the Swansway Chester Stadium.
Matip, who has not played since sustaining a thigh injury in March, is set to return to full training next week, while Lallana is struggling with illness.
Virgil van Dijk and Georginio Wijnaldum will also miss this weekend’s game, with the Dutch duo scheduled to start pre-season training at Melwood on Sunday after being afforded extra time off due to international commitments at the end of 2017-18.