Liverpool FC Women suffered a 3-0 defeat at the hands of Manchester City Women in the Continental Cup on Wednesday afternoon.
The Reds were unable to build on the win over Manchester United in their tournament opener last month after goals from Laura Coombs, Rose Lavelle and Jess Park at Prenton Park.
Vicky Jepson's side will conclude their Group C campaign later this month when they travel to local rivals Everton.
Wednesday's visitors, fresh from their victory in the Women's FA Cup final on the weekend, were on the front foot all throughout the encounter.