The Reds lost 2-0 at Napoli in the opening game of their continental campaign but have been in formidable form at home.
Jürgen Klopp's side are unbeaten in their last 22 matches at Anfield in Europe, winning 16, and memorably beat Barcelona 4-0 the last time they played in the Champions League in L4.
However, Austrian champions Salzburg head into this clash buoyed by a 6-2 thrashing of Genk on matchday one and sit top of Group E.
Here are three key battles that could decide their showdown...
Virgil van Dijk v Erling Haaland
Champions League winner, UEFA Men's Player of the Year, named in the FIFA FIFPro Men's World11 and a key part of the most miserly defence in the Premier League.