Liverpool manager Jurgen Klopp will recall a host of senior players after making nine changes in midweek.
Alexis Mac Allister, Joel Matip, Thiago Alcantara, Diogo Jota, Stefan Bajcetic and Any Robertson remain sidelined.
Manchester United captain Bruno Fernandes is suspended after accumulating five yellow cards.
Harry Maguire is ruled out after being injured against Bayern Munich but Luke Shaw may be available despite being forced off during that game.
Marcus Rashford returns after missing out through illness in midweek, though Anthony Martial is not yet well enough to feature.
Tyrell Malacia, Casemiro, Lisandro Martinez, Mason Mount, Christian Eriksen and Amad Diallo are all injured.